Hypersensitivity reactions with allopurinol and febuxostat: a study using the Medicare claims data

Study found allopurinol (HR 1.32; 95% CI, 1.10-1.60) and febuxostat (1.54; 1.12-2.12) similarly increased risk of hypersensitivity reactions vs. colchicine and did not differ from each other. In allopurinol users, starting dose, female sex and diabetes increased this risk.


Annals of the Rheumatic Diseases