Hypersensitivity reactions with allopurinol and febuxostat: a study using the Medicare claims data

Study found allopurinol (HR 1.32; 95% CI, 1.10-1.60) and febuxostat (1.54; 1.12-2.12) similarly increased risk of hypersensitivity reactions vs. colchicine and did not differ from each other. In allopurinol users, starting dose, female sex and diabetes increased this risk.

Source:

Annals of the Rheumatic Diseases