Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis

Review (35 studies;n = 8033 pregnancies) noted lower gestational weight gain in pregnancies randomised to metformin (MF) vs. other treatments (p < 0.0001), as was likelihood of pre-eclampsia (OR 0.69, 95% CI 0.50–0.95;p = 0.02) but risk of GI side-effects was greater in MF groups

Scientific Reports