Inappropriate empirical antibiotic therapy for bloodstream infections based on discordant in-vitro susceptibilities: a retrospective cohort analysis of prevalence, predictors, and mortality risk in US hospitals

Cohort analysis of data from 131 hospitals in the US (21,068 patients with bloodstream infections) found that 19% had discordant empirical antibiotic therapy, which was independently associated with increased risk of mortality (adjusted OR 1·46, 95%CI 1·28–1·66).

The Lancet Infectious Diseases