Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia
RCT (n=482) found that patients on subcutaneous injections of inclisiran, a small interfering RNA targeting hepatic PCSK9 synthesis (300mg) on days 1, 90, 270, and 450 had significantly lower levels of LDL cholesterol vs. placebo, with an acceptable safety profile.
Source:
New England Journal of Medicine
SPS commentary:
In terms of the two primary end points:
Data from the ORION-10 and ORION-11 trials (n=1561 and 1617, respectively) also published in the journal found that reductions in LDL cholesterol levels of ~50% were obtained with inclisiran administered subcutaneously every 6 months.