Individual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials

Meta-analysis of 87 RCTs(n=17,540) found variability in responses among patients on antidepressants (ADs) that was 14% greater vs.those on placebo, suggesting possible moderators systematically linked to responses to ADs beyond nonspecific (placebo) effects or statistical factors

JAMA Psychiatry