Indomethacin for symptomatic patent ductus arteriosus in preterm infants

Review (14 RCTs; n=880) found high‐certainty evidence that indomethacin is effective in closing a symptomatic patent ductus arteriosus vs. placebo or no treatment, Evidence is insufficient regarding effects of indomethacin on other clinically relevant outcomes and ADRs.

Cochrane Database of Systematic Reviews