Influence of Clinical Trials of Acute Coronary Syndrome Beyond the Primary Hypothesis: A Systematic Review

Review of 25 trials found trials that did not achieve their primary objective had fewer primary citations (median, 443 vs 868; p =0.006). Frequency of secondary analyses (SA) peaked within 5 years of primary trial at 643. Trials that did not achieve primary objective had fewer SA


JAMA Cardiology