Integrated management of atrial fibrillation in primary care: results of the ALL-IN cluster randomized trial

RCT (n=1240, Netherlands) found that integrated care for elderly AF patients in primary care showed a 45% reduction in all-cause mortality when compared with usual care (3.5 vs. 6.7 per 100 patient-years, respectively, HR 0.55; 95% CI, 0.37–0.82].

SPS commentary:

Intervention consisted of:


  • Quarterly AF check-ups by trained nurses in primary care, also focusing on possibly interfering comorbidities.
  • Monitoring of anticoagulation therapy in primary care.
  • Easy-access availability of consultations from cardiologists and anticoagulation clinics.


European Heart Journal