Intensity of statin therapy and muscle symptoms: a network meta-analysis of 153,000 patients

Review (24 RCTs;n=152,461) found risk of myalgia & cessation of therapy due to muscle problems more frequent with high dose (HD) vs moderate dose (MD) statins (RR 1.04, 95% CI 1.00-1.08& 1.37;1.09-1.73) so for ~each 200 pts on HD,1 additional pt may experience these issues vs.MD

BMJ Open