Isoniazid preventive therapy plus antiretroviral therapy for the prevention of tuberculosis: a systematic review and meta-analysis of individual participant data

Review of 3 trials (n=2,611) found addition of isoniazid preventative therapy to antiretroviral treatment (ART) in HIV reduced the risk of tuberculosis vs ART alone (HR 0.68, 95%CI 0.49-0.95, p=0.02) but there was no significant difference in all-cause mortality.

Source:

The Lancet HIV