Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

Meta-analysis of 15 trials claims there is moderate-certainty evidence suggesting reductions in COVID-19 deaths are possible using ivermectin; whilst low-certainty evidence indicates there may be no benefit in terms of need for mechanical ventilation.

SPS commentary:

When the European Medicines Agency reviewed the data in March for the prevention and treatment of COVID-19, it concluded that the available data do not support its use for COVID-19 outside well-designed clinical trials.

American Journal of Therapeutics

Resource links:

European Medicines Agency review