Acute Toxicity Related to Misuse (Non‐Medical Use) of Tramadol: Experience of the European Drug Emergencies Network Plus (Euro‐DEN Plus) Project

Of 24,957 emergency department presentations (Jan 2014 – Dec 2017), tramadol misuse was reported in 105 patients of which 14 were in coma/GCS≤8 and 9 had a respiratory rate <12 per minute, suggesting a significant burden for emergency department care.


British Journal of Clinical Pharmacology