Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen

Review (4 RCTs; n=543) found LNG‐IUS probably slightly reduces incidence of benign endometrial (EN) polyps and hyperplasia in this population and at 12 and 24 months, it probably increases abnormal vaginal bleeding vs. control. Data were lacking on whether it prevents EN cancer.

Source:

Cochrane Database of Systematic Reviews