Long‐term effects of weight‐reducing drugs in people with hypertension

Review (6 RCTs; n=12,724) found largest weight reduction with phentermine/topiramate but marketing authorisation refused due to safety concerns . Naltrexone/bupropion did not reduce BP or reduce all‐cause mortality or cardiovascular mortality/morbidity after 2 years vs placebo.

Source:

Cochrane Database of Systematic Reviews