Low-Dose Tamoxifen for Mammographic Density Reduction: A Randomized Controlled Trial

RCT (n=1,439) found that 2.5mg, 5mg and 10mg tamoxifen provided a non-inferior reduction in mammographic density vs 20 mg, and rates of severe vasomotor symptoms were 50% lower. Authors highlight future studies should test if 2.5 mg reduces risk of primary breast cancer.

Source:

Journal of Clinical Oncology