Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus

Review of 20 RCTs (n=6,774) found that metformin compared with placebo or diet and exercise reduced or delayed risk of type 2 diabetes mellitus (T2DM) in people at increased risk. However, metformin compared to intensive diet and exercise did not reduce or delay the risk of T2DM.

Source:

Cochrane Database of Systematic Reviews