Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome

This updated review (13 RCTs; n=1132) found no conclusive evidence that use of metformin before or during IVF/ICSI treatment in women with PCOS improves live birth rates. It may reduce incidence of ovarian hyperstimulation syndrome but increase risk of side-effects.

Cochrane Database of Systematic Reviews