MHRA publishes first report on adverse reactions to approved Covid-19 vaccines submitted via the Yellow Card Scheme

This report, which summarises information received via the Yellow Card scheme, shows the safety profiles of the Covid-19 vaccines approved by the MHRA remain positive, are consistent with clinical trial data, and the benefits continue to outweigh any known side-effects.

SPS commentary:

At the time of the analysis there were 22,820 reports of suspected side-effects (equivalent to a rate of 3 in 1,000 doses). Individual analysis prints are available for each of the vaccines (Pfizer; AstraZeneca; brand unspecified). Overall, the majority of reports relate to injection-site reactions and generalised symptoms such as ‘flu-like’ illness, headache, chills, nausea and fever.


This is the first of what will be regular Covid-19 vaccine safety reports, reported through the Yellow Card scheme. The MHRA is working to actively promote reporting on suspected side-effects from Covid-19 vaccines from both patients and healthcare professionals, through this scheme.


Medicines and Healthcare products Regulatory Agency

Resource links:

Press release


Pfizer vaccine analysis print

AstraZeneca vaccine analysis print

Brand unspecified analysis print