Mirtazapine use may increase the risk of hypothyroxinemia in patients affected by major depressive disorder

Retrospective cohort study (n=220, China) found use of mirtazapine associated with increased risk of developing hypothyroxinemia (low concentration of thyroxine), occurring in 37.5% on treatment vs 19.7% non-users (RR 1.70; 95% CI; 1.21-2.43).

British Journal of Clinical Pharmacology