Mortality in STEMI patients without standard modifiable risk factors: a sex-disaggregated analysis of SWEDEHEART registry data
Review of the SWEDEHEART study (n=62,048) found those with a STEMI in the absence of standard modifiable cardiovascular risk factor (SMuRF e.g. hypertension, smoking) have an increased risk of all-cause mortality vs those with at least one SMuRF (HR 1·47, 95%CI 1·37–1·57).
Source:
The Lancet
SPS commentary:
The increased risk was particularly evident in women and 30-day mortality was highest in SMuRF-less women which was 17·6%, as compared to 9.3% for men without a SMuRF and 6.1% for men with at least 1 SMuRF respectively.
A related commentary concludes new sex-specific risk factors and risk markers should be implemented in clinical risk models that can identify high-risk individuals among SMuRF-less patients with STEMI. Improvement in risk stratification and accurate diagnosis would help to tailor treatment in SMuRF-less patients, reducing the excess mortality and avoiding undertreatment in this subgroup.