Mucoactive agents for acute respiratory failure in the critically ill: a systematic review and meta-analysis

Review of 13 RCTs (n=1,712) found that mucoactive agents showed no effect on duration of mechanical ventilation, mortality, hospital stay or ventilator free days, though there was a reduction in length of ICU stay vs placebo/standard of care (-3.22 days, 95% CI -5.49 to -0.96)