Multisystem Inflammatory Syndrome in Children in New York State
Study (n=95) reports emergence of multisystem inflammatory syndrome coincided with widespread SARS-CoV-2 transmission; and this hyperinflammatory syndrome with dermatologic, mucocutaneous, and gastrointestinal manifestations, was associated with cardiac dysfunction.
Source:
New England Journal of Medicine
Resource links:
Editorial:
https://www.nejm.org/doi/full/10.1056/NEJMe2023158
Feldstein et al study:
SPS commentary:
Authors of a related editorial highlight that as the coronavirus disease 2019 pandemic has evolved, case reports have appeared describing children with unusual febrile illnesses that have features of Kawasaki’s disease, toxic shock syndrome, acute abdominal conditions, and encephalopathy, along with other reports of children with fever, elevated inflammatory markers, and multisystem involvement. They state it is now apparent that these reports were describing different clinical presentations of paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); a new childhood inflammatory disorder.
A second report by Feldstein and colleagues has been published in this journal, which also describes the epidemiology and clinical features of the new disorder in the United States.