Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients

Study (n=700) reports among mechanically ventilated ICU patients, mortality at 90days did not differ significantly between those on no sedation v those assigned to a plan of light sedation with daily interruption (42.4% v 37.0%, difference 5.4%; RR 1.1, 95% CI −2.2-12.2; P=0.65).

SPS commentary:

In a related editorial, the authors discuss the inclusion criteria for patients enrolled, and reinforce the need to monitor sedation clinically with the aim of discontinuing it as early as possible or at least interrupting it daily.


New England Journal of Medicine

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