Off-label Use of Direct Oral Anticoagulants Compared With Warfarin for Left Ventricular Thrombi

Study (n=514) found DOAC linked to higher risk of stroke/systemic embolism vs. warfarin (HR 2.71; 95% CI, 1.31-5.57; p= 0.01), challenging assumption of DOAC equivalence with warfarin for LV thrombi and highlights need for RCTs to determine most effective treatment strategies.


JAMA Cardiology