Once-Weekly Semaglutide in Adults with Overweight or Obesity

RCT (n=1,961) reports 2.4 mg semaglutide once weekly & lifestyle intervention resulted in significant reduction in body weight at wk 68 vs. placebo (mean change −14.9% vs. −2.4%, respectively; estimated treatment difference −12.4 percentage points (95% CI −13.4 to −11.5; p<0.001)

New England Journal of Medicine