Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study

Study of 37,650 pregnancies exposed to oral fluconazole and 82,090 to topical azoles found oral fluconazole use in first first trimester not linked to oral clefts or conotruncal malformations, but was linked to musculoskeletal malformations (RR 1.30; 95% CI, 1.09 to 1.56)

British Medical Journal