Oral nitrate supplementation to enhance pulmonary rehabilitation in COPD: ON-EPIC a multicentre, double-blind, placebo-controlled, randomised parallel group study

RCT (n=165) reports exercise capacity improved more with dietary nitrate supplementation vs. placebo; median change in incremental shuttle walk distance +60 m vs +30 m, respectively, estimated treatment effect 30 m (95% CI 10 to 40), p=0.027.

Thorax