Orthopaedic corticosteroid injections and risk of acute coronary syndrome: a cohort study

Review of 60,856 orthopaedic visits (22 131 individual patients) found that those who had received a corticosteroid injection were more likely to experience a subsequent acute coronary syndrome vs those who had not (227 vs 31 events per 100,000 visits, OR 7.3, 95%CI 2.8-19.1).

SPS commentary:

Authors report that although the absolute risk is small, the effect size appears to be clinically significant.  The association between corticosteroid injection and acute coronary syndromes remained similar when the analysis was restricted to subgroups defined by age, sex, and cardiovascular risk factors.

British Journal of General Practice