Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

RCT (n=80) found pegcetacoplan (PC) superior to eculizumab (EC) with respect to change in haemoglobin level from baseline to week 16, with adjusted mean difference of 3.84g/dL (p<0.001); and 35 patients (85%) on PC no longer required transfusions vs. 6 patients (15%) on EC.

New England Journal of Medicine