Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison

Study reports that 4 commercial, widely available assays and a scalable 384-well ELISA can be used for SARS-CoV-2 serological testing to achieve sensitivity and specificity of ≥98%. The Siemens assay and Oxford immunoassay achieved these metrics without further optimisation.

SPS commentary:

According to a commentary, further work is required to investigate what titre of neutralising antibodies correlates with protection, how long neutralisation activity persists, and which assay best predicts that. It adds that identifying an appropriate assay will be crucial for assessing vaccine responses, and for assessing potential risk of reinfection, which has been shown with seasonal coronaviruses, but not so far for SARS-CoV-2.

 

The Lancet Infectious Diseases