Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy

Current evidence (34 RCTs; n=1960) does not support overall superiority of any anticoagulant. Compared to unfractionated heparin, citrate probably reduces major bleeding and probably has little or no effect on preventing clotting or death at 28 days. Further studies are required.


Cochrane Database of Systematic Reviews