Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP: A Randomized Trial

In RCT (n=244), this selective histamine H3-receptor antagonist with wake-promoting effects used as adjunct to CPAP therapy in this population reduced subjective and objective sleepiness (reduced Epworth Sleepiness Scale score vs. placebo (−2.6; p<0.001)