Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis

This analysis of 59 studies (21 countries) found a summary prevalence of mutations associated with macrolide resistance of 10.0% before 2010 and 51.4% in 2016-17. The overall prevalence of mutations associated with fluoroquinolone resistance was 7.7% (no change over time).

SPS commentary:

A related comment notes that infection with Mycoplasma genitalium is now accepted as an important sexually transmitted infection, with a prevalence of around 1% in high-income countries. It is a causative agent of non-gonococcal urethritis in men and cervicitis and pelvic inflammatory disease in women, and there is accumulating evidence to suggest it is also an important cause of spontaneous abortion and preterm birth, and a possible cofactor for increased transmission of HIV.


The Lancet Infectious Diseases

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