Prevalence of statin intolerance: a meta-analysis

Review of 176 studies (112 RCTs and 64 cohort studies, n=4,143,517) found a prevalence of statin intolerance of 9.1%. Statin lipid solutbility did not affect prevalence, but age, female gender, diabetes, hypothyroidism & Asian or Black race were associated with statin intolerance

SPS commentary:

Authors highlight the prevalence of statin intolerance was low when diagnosed according to international definitions and the results support the concept that the prevalence of complete statin intolerance might often be overestimated and highlight the need for the careful assessment of patients with potential symptoms related to statin intolerance.

European Heart Journal