Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy

This updated review (32 RCTs [6 new]; n=15,678) found LMWH reduce, and direct factor Xa inhibitors may reduce, incidence of symptomatic VTE; both likely increase risk of major bleeding. Evidence for use of thromboprophylaxis with other anticoagulants is limited.

Cochrane Database of Systematic Reviews