Primary Tumor Resection Plus Chemotherapy Versus Chemotherapy Alone for Colorectal Cancer Patients With Asymptomatic, Synchronous Unresectable Metastases (JCOG1007; iPACS): A Randomized Clinical Trial

RCT (n=165) found primary tumor resection (PTR) before chemotherapy showed no survival benefit over chemotherapy alone. Three postoperative deaths occurred in the PTR plus chemotherapy arm.

Journal of Clinical Oncology