Progesterone to prevent miscarriage in women with early pregnancy bleeding: the PRISM RCT

RCT (n=4153 from 48 UK hospitals) found progesterone therapy in first trimester of pregnancy did not result in a significantly higher rate of live births among women with threatened miscarriage overall compared with placebo (live birth rate 75% vs. 72%, respectively; p = 0.08).


National Institute for Health Research