Psychological interventions as an alternative and add-on to antidepressant medication to prevent depressive relapse: systematic review and meta-analysis

Review (11 trials; n=1559) found no evidence to suggest adding a psychological intervention (PI) to tapering increases risk of relapse vs. antidepressants (ADs) alone; and adding a PI to AD use reduces relapse risk significantly vs. ADs alone (RR 0.85, 95% CI 0.74–0.97; p= 0.01).

British Journal of Psychiatry