Reappraisal of the treatment duration of antibiotic regimens for acute uncomplicated cystitis in adult women: a systematic review and network meta-analysis of 61 randomised clinical trials

Review of 61 RCTs (n=20,780) suggests shorter courses of third- and fourth-generation fluoroquinolones than that currently recommended are associated with similar effects; evidence for third generation cephalosporins and co-amoxiclav was of low quality.

SPS commentary:

A related comment notes that the authors are rightfully cautious in their conclusions, noting that the studies had methodological flaws and that further research is needed to confirm the findings.


The Lancet Infectious Diseases

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