Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

Study found no substantial increase in likelihood of positive Covid-19 test or risk of severe Covid-19 among 12,594 patients who tested positive in association with ACE inhibitors, angiotensin-receptor blockers, beta-blockers, calcium-channel blockers, or thiazide diuretics).

SPS commentary:

An accompanying editorial discusses the implications of this study and two other related studies, noting that whilst all studies are observational studies with the potential for confounding, none of them demonstrated evidence of harm with continued use of ACE inhibitors and ARBs.


New England Journal of Medicine

Resource links:


Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19