Revised SPC: Betnesol-N (neomycin sulfate betamethasone sodium phosphate) Eye, Ear and Nose Drops

SPC highlights warnings of increased risk of ototoxicity with aminoglycosides administered to pts with mitochondrial mutations, particularly the m.1555A>G mutation, including cases where aminoglycoside levels were within recommended range. The incidence of this effect is unknown.

Source:

electronic Medicines compendium