Revised SPC: Dailiport and Adoport (tacrolimus) – all presentations

SPC now warns co-administration with metamizole, an inducer of metabolising enzymes including CYP2B6 and CYP3A4 may cause a reduction in plasma levels of tacrolimus with potential decrease in clinical efficacy. (metamizole [Nolotil] is an analgesic that is not available in UK).

Source:

electronic Medicines compendium