Revised SPC: Emerade (adrenaline) solution for injection in pre-filled pen – all strengths
Section 4.2 states Emerade should be administered at first sign of anaphylaxis. Section 4.4 warns in patients with a thick subcutaneous fat layer, there is risk of adrenaline being administered in fat tissue which may result in suboptimal effect and need for a second dose.
Source:
electronic Medicines compendium