Revised SPC: Fentanyl (Effentora) Buccal Tablets

SPC now notes opioids can cause sleep-related breathing disorders including central sleep apnoea (CSA) and sleep-related hypoxemia. Opioid use increases the risk of CSA in a dose-dependent fashion. In patients who present with CSA, consider decreasing the total opioid dosage.

Source:

electronic Medicines compendium