Revised SPC: Fentanyl (Effentora) Buccal Tablets
SPC now notes opioids can cause sleep-related breathing disorders including central sleep apnoea (CSA) and sleep-related hypoxemia. Opioid use increases the risk of CSA in a dose-dependent fashion. In patients who present with CSA, consider decreasing the total opioid dosage.
Source:
electronic Medicines compendium