Revised SPC: Frisium (clobazam) 10mg Tablets

SPC updated to warn that co-administration of cannabidiol with clobazam can elevate levels of N-desmethylclobazam which may lead to increased ADR (somnolence and sedation), likely medicated by CYP2C19 inhibition. Dosage adjustment of clobazam may be necessary.

Source:

electronic Medicines compendium