Revised SPC: Indivina (estradiol valerate and medroxyprogesterone acetate) tablets

Exacerbation of angioedema has been added as a potential adverse effect of treatment (frequency unknown), and caution is recommended in patients with a history of angioedema. SPC also notes many HIV/HCV antivirals can increase or decrease plasma concentrations of oestrogen.

Source:

electronic Medicines compendium