Revised SPC: Indocid (indomethacin) Suppositories 100 mg

SPC now highlights that studies in premature neonates being treated for patent ductus arteriosus have shown that concomitant administration of indometacin and vancomycin may have additive nephrotoxic effects, as indometacin may increase the risk of vancomycin related toxicities.

Source:

electronic Medicines compendium