Revised SPC: Marcain (bupivacaine) Polyamp Steripack 0.25 and 0.5%

SPC now warns that hepatic dysfunction, with reversible increases of ALT, AlkP and bilirubin, has been observed following repeated injections or long-term infusions. Link with drug-induced liver injury also reported in some literature reports especially with prolonged use.

Source:

electronic Medicines compendium