Revised SPC: Orkambi (lumacaftor and ivacaftor) 100 mg/125 mg granules in sachet

Various updates include change to dosing recommendation for patients taking concomitant clarithromycin, telithromycin itraconazole, ketoconazole, posaconazole or voriconazole (one sachet every other day instead of once daily), and addition of paediatric long-term safety data.

Source:

electronic Medicines compendium