Revised SPC: Symtuza (cobicistat; darunavir; emtricitabine; tenofovir) and Rezolsta (cobicistat; darunavir) tablets

SPC of both products warns that co-administration with clopidogrel is not recommended due to an expected decrease in the plasma concentration of the active metabolite of clopidogrel, which may reduce its antiplatelet activity.

Source:

electronic Medicines compendium